What is the optimal duration of treatment for eradicating Helicobacter pylori infection?
Overall, the quality of evidence for the outcome of H. pylori persistence for PPI triple therapy was moderate because of study limitations (risk of bias). For certain subgroups, the quality of the evidence for the outcome H. pylori persistence was low (eg, PCN 14 days versus 7 days) or very low (eg, PCN 10 days versus 7 days) because of study limitations.
A PPI plus 2 antibiotics is the most commonly used first treatment to eradicate H. pylori infection. The ideal duration of therapy for H. pylori eradication is controversial, with recommendations ranging from 7 to 14 days.